TH 257 - Names and Identifiers
TH 257 - Physico-chemical Properties
Molecular Formula | C24H26N2O3S
|
Molar Mass | 422.54 |
Solubility | DMSO : 250 mg/mL (591.66 mM; Need ultrasonic) |
Storage Condition | 2-8°C |
TH 257 - Preparation solution concentration reference
| 1mg | 5mg | 10mg |
---|
1 mM | 2.367 ml | 11.833 ml | 23.666 ml |
5 mM | 0.473 ml | 2.367 ml | 4.733 ml |
10 mM | 0.237 ml | 1.183 ml | 2.367 ml |
5 mM | 0.047 ml | 0.237 ml | 0.473 ml |
Last Update:2024-01-02 23:10:35
TH 257 - Reference Information
biological activity | TH-257 is a potent, highly selective inhibitor of LIM kinase (LIMK), the IC50 values for LIMK1 and LIMK2 were 84 nM and 39 nM, respectively. |
Target | Value |
LIMK2
(Cell-free assay)
| 39 nM |
LIMK1
(Cell-free assay)
| 84 nM |
Last Update:2024-04-09 21:32:10